Avian leukosis virus is a versatile eukaryotic platform for polypeptide display

Efficient method to optimize antibodies using avian leukosis virus display and eukaryotic cells.

Antibody-based therapeutics have now had success in the clinic. The affinity and specificity of the antibody for the target ligand determines the specificity of therapeutic delivery and off-target side effects. The discovery and optimization of high-affinity antibodies to important therapeutic targets could be significantly improved by the availability of a robust, eukaryotic display technology...

Avian Leukosis Virus

Ultrastructural studies of chick embryo cells morphological ly altered by strain MC29 avian leukosis virus revealed marked and characteristic differences from normal cells and cells al tered by infection with other avian tumor viruses. Such differ ences were manifest in part in the cytoplasm by high content of free ribosomes, poorly developed rough endoplasmic reticu lum, frequent fat droplets,...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

A novel subgroup of exogenous avian leukosis virus in chickens.

An avian leukosis virus with a wide host range belonging to a new subgroup for chickens was isolated from meat-type chicken lines. The virus, of which HPRS-103 strain is the prototype, was of low oncogenicity in chickens but appeared to behave like an exogenous leukosis virus. Neutralizing antibodies to the virus were found in three of five meat-type chicken lines, but not in seven layer lines....

Domestic chickens activate a piRNA defense against avian leukosis virus

PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens. Here we reported that all active TEs in the chicken germ line are targeted by piRNAs, and as TEs lose their activity, the corresponding piRNAs erode away. We observed de novo piRNA birth as host responds to...